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KMID : 0604520070330010023
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Journal of the Society of Cosmetic Scientists of Korea
2007 Volume.33 No. 1 p.23 ~ p.28
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Enhanced Transdermal Delivery of Vitamin C Derivative using lontophoretic Gel Patch with Flexible Thin Layer Battery
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Cho Wan-Goo
Rang Mun-Jeong
Song Young-Sook
Lim Young-Ho
Park Hyeon-Woo
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Abstract
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Ascorbic acid (vitamin C, AsA) has been known as a strong reducing agent and is supposed to retard the synthesis of melanin pigment. A main problem that arose in using vitamin C in cosmetic formulation was its poor stability and low skin permeability, which result in low lightening efficacy in clinical trials. In this study, iontophoretic gel patch with flexible thin layer battery was employed in order to enhance skin permeation of vitamin c derivative (ascorbyl glucoside, AsAG) and to increase its lightening efficacy. in vitro iontophoretic skin permeation and stability of AsAG, safety and clinical lightening efficacy of iontophoretic patch containing 2% AsAG solution were examined. A optimun current of ionthophoretic patch for korean women was 0.1 mA, considering the skin permeability and skin irritation of consumers. We suggest that iontophoretic gel patch could be a safe system for enhancing the skin permeation of AsAG and lightning efficacy.
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KEYWORD
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vitamin C derivative, iontophoresis, skin whitening, flexible thin layer battery, tropical delivery
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